Ochratoxin a in Maize: Origin, Occurrence, and Health Implications, Albania Case

Authors

  • Griserda TOPI Department of Chemistry, Faculty of Natural Sciences, University of Tirana, Tirana, Albania Author
  • Dritian TOPI Department of Chemistry, Faculty of Natural Sciences, University of Tirana, Tirana, Albania Author

DOI:

https://doi.org/10.65888/icraft.3.1.13

Keywords:

Mycotoxins, Ochratoxin A, Maize, Albania, Food And Feed Safety, Nephrotoxic

Abstract

Mycotoxins are toxic secondary metabolites produced by fungi that frequently contaminate cereal grains, compromising food safety. Among the most concerning are aflatoxins and ochratoxin A (OTA), primarily produced by Aspergillus and Penicillium species. OTA contamination typically occurs under warm, humid conditions, especially during poor post-harvest storage. Albania’s maize-growing regions—Lushnja, Fieri, Korça, Shkodra, and Elbasan—are climatically predisposed to such risks. Although OTA is not the most prevalent mycotoxin in Albanian maize, recent findings confirm its presence in samples linked to inadequate storage. OTA is nephrotoxic and has been associated with renal damage and Balkan Endemic Nephropathy. While the OTA incidence on Albanian maize is relatively low, the risk assessment indicate high concentration levels for OTA in positive contaminated samples. Poor storage and limited monitoring elevate the crop vulnerability. These findings underscore the need for systematic testing and improved post-harvest practices to mitigate contamination and protect public health.

References

1. Abbas, H.K., Zablotowicz, R.M., Weaver, M.A., Shier, W.Th., Bruns, H.A., Bellaloui, N., Accinelli, C. and Abel, C.A. (2013). Implications of Bt Traits on Mycotoxin Contamination in Maize: Overview and Recent Experimental Results in Southern United States. Journal of Agricultural and Food Chemistry, 61, 11759−11770, doi.org/10.1021/jf400754g

2. Altomare, C., Logrieco, A. F., & Gallo, A. (2021). Mycotoxins and mycotoxigenic fungi: risk and management. A challenge for future global food safety and security.

3. Atanda, S.A., Pessu, P.O., Agoda, S., Isong, I.U., Adekalu, O.A., Echendu, M.A. & Falade T.C. (2011). Fungi

and mycotoxins in stored foods. African Journal of Microbiology Research, 5(25), 4373-4382, DOI: 10.5897/AJMR11.487

4. Bullerman, L. B., & Bianchini, A. (2014). 7 good food-processing techniques: Stability of mycotoxins in processed maize-based foods. In Mycotoxin reduction in grain chains (p. 89).

5. Channaiah, L., & Maier, D. E. (2014). Best stored maize management practices for the prevention of mycotoxin contamination. In Mycotoxin reduction in grain chains (p. 78).

6. D’Mello, J.P.F. (2003). Mycotoxins in Cereal Grains, Nuts and Other Plant Products, in Food Safety: Contaminants and Toxins, Ed. J.P.F. D’Mello, CABI International, Wallingford, UK, 65-91.

7. FAO. (2011). National stakeholders workshop on aflatoxin control along the maize value from 28-30th September 2011. Nairobi, Kenya.

8. Fumagalli, F., Ottoboni, M., Pinotti, L., Cheli, F. (2021). Integrated Mycotoxin Management System in the Feed Supply Chain: Innovative Approaches. Toxins (Basel), 13(8), 572. doi: 10.3390/toxins13080572.

9. Gallo, A. Bruno, K.S. Solfrizzo, M. Perrone, G. Mulè, G. Visconti, A. and Baker, S.E. (2012). New Insight into the Ochratoxin A Biosynthetic Pathway through Deletion of a Non-ribosomal Peptide Synthetase Gene in Aspergillus carbonarius. Applied and Environmental Microbiology, 78/2, 8208 – 8218.

10. Harris, J.P., Mantle, P.G. (2001). Biosynthesis of ochratoxins by Aspergillus ochraceus. Phytochemistry, 558, 709 –716.

11. Huff, W.E., Hamilton, P.B. (1979). Mycotoxins—their biosynthesis in fungi: ochratoxins—metabolites of combined pathways. Journal of Food Protection, 42, 815–820.

12. Kabak, B., Dobson, A. D., & Var, I. l (2006). Strategies to prevent mycotoxin contamination of food and animal feed: A review. Critical Reviews in Food Science and Nutrition, 46(8), 593-619.

13. Kolawole, O., Siri-Anusornsak, W., Petchkongkaew, A., Elliott, Ch. (2024). A systematic review of global occurrence of emerging mycotoxins in crops and animal feeds, and their toxicity in livestock. Emerging Contaminants, 10/3, 100305, doi: 10.1016/j.emcon.2024.100305.

14. Kőszegi, T, & Poór, M. (2016). Ochratoxin A: Molecular Interactions, Mechanisms of Toxicity and Prevention at the Molecular Level. Toxins (Basel). 8(4), 111. doi: 10.3390/toxins8040111.

15. Kumar D, Kalita P. (2017). Reducing Postharvest Losses during Storage of Grain Crops to Strengthen Food Security in Developing Countries. Foods. 6(1), 8. doi: 10.3390/foods6010008.

16. Magan N, Aldred D. (2007). Post-harvest control strategies: minimizing mycotoxins in the food chain. International Journal of Food Microbiology, 119(1-2), 131-9. doi: 10.1016/j.ijfoodmicro.2007.07.034.

17. Mato, L., Damani, Z., Spahiu, J., Halimi, E., Seiti, B., Topi, D. (2024). High Prevalence of Mycotoxigenic Fungi and Aflatoxin B1 Contamination in Corn and Wheat Grains Grown to Albania: Implications for Food Safety. Journal of Food Quality and Hazards Control, 11(1), 59-68.

18. Medina A, Rodriguez A, Magan N. (2014). Effect of climate change on Aspergillus flavus and aflatoxin B1 production. Frontiers in Microbiology. 5, 348. doi: 10.3389/fmicb.2014.00348.

19. Mendoza Jiménez, J.R., Channaiah, L.H. & Bianchini, A. (2025). Mycotoxins in cereal grains, in : Food Safety, Eds: A. Bianchini, J. Stratton, Elsevier, 163-222, doi:10.1016/B978-0-12-819340-2.00008-0.

20. Milani, J. (2013). Ecological conditions affecting mycotoxin production in cereals: A review. Veterinarni Medicina, 58(8), 405-411.

21. Munkvold, G. P., Arias, S., Taschl, I., & Gruber-Dorninger, C. (2019). Mycotoxins in Corn: Occurrence, Impacts, and Management. In Corn (pp. 235-287). https://doi.org/10.1016/b978-0-12-811971-6.00009-7

22. Neme, K., & Mohammed, A. (2017). Mycotoxin occurrence in grains and the role of postharvest management as a mitigation strategy, a review. Food Control, 78, 412-425. https://doi.org/10.1016/j.foodcont.2017.03.012

23. Pavlović, N.M. (2013). Balkan endemic nephropathy—Current status and future perspectives. Clinical Kidney Journal. 6, 257–265. doi: 10.1093/ckj/sft049.

24. Pitt, J. I., Taniwaki, M. H., & Cole, M. B. (2013). Mycotoxin production in major crops as influenced by growing, harvesting, storage and processing, with emphasis on the achievement of Food Safety Objectives. Food Control, 32(1), 205-215. https://doi.org/10.1016/j.foodcont.2012.11.023

25. Pitt, J.I. & Hocking, A.D. (2022). Fungi and food spoilage, 4th ed. London, Springer.

26. Ringot, D., Chango, A., Schneider, Y.J., Larondelle, Y. (2006). Toxicokinetics and toxicodynamics of ochratoxin A, an update. Chemico-Biological Interactions, 159, 18–46.

27. Singh, K., Kumari, A. (2022). Mycotoxins Co-occurrence Poisoning. In: Mycotoxins and Mycotoxicoses. Springer, Singapore. https://doi.org/10.1007/978-981-19-2370-8_6

28. Smith, M.C., Madec, S., Coton, E., Hymery, N. (2016). Natural Co-Occurrence of Mycotoxins in Foods and Feeds and Their in vitro Combined Toxicological Effects. Toxins (Basel), 8(4), 94. doi: 10.3390/toxins8040094.

29. Sweeney, M.J., & Dobson, D.W. (1998). Mycotoxin production by Aspergillus, Fusarium and Penicillium species. International Journal of Food Microbiology, 43, 141–158.

30. Tahiri, A., Risto, J., Mato, L., Cani, A., & Topi, D. (2025). Occurrence of Aflatoxin M1 in Milk Consumed in Tirana, Albania, and Health Risk Assessment in Different Population Groups. Toxins, 17(7), 315. https://doi.org/10.3390/toxins17070315

31. Topi, D. Babič, J. Pavšič-Vrtač, K. Tavčar-Kalcher, G. Jakovac-Strajn, B. (2021). Incidence of Fusarium Mycotoxins in Wheat and Maize from Albania. Molecules, 26(1), 172. doi: 10.3390/molecules26010172.

32. Topi, D., Babic, J., Jakovac-Strajn, B., Tavcar-Kalcher, G. (2023). Incidence of Aflatoxins and Ochratoxin A in Wheat and Corn from Albania. Toxins. 15(9), DOI:10.3390/toxins15090567.

33. Topi, D., Babič, J., Pavšič-Vrtač, K., Tavčar-Kalcher, G., Jakovac-Strajn, B. (2017). Occurrence of ergot alkaloids in wheat from Albania. Food Additives and Contaminants. Part A. 34:1333–1343. DOI:10.1080/19440049.2017.1307528.

34. Topi, D., Damani, Z., Babič, J., Jakovac-Strajn, B. and Tavčar-Kalcher, G. (2024). The Presence of Some Minor Aspergillus and Penicillium Unregulated Mycotoxins in Main Cereals Cultivated in Albania. Molecules. 29(22):5292. DOI:10.3390/molecules29225292.

35. Topi, D., Tavčar-Kalcher, G., Pavšič-Vrtač, K., Babič, J. & Jakovac-Strajn, B. (2019). Alternaria mycotoxins in grains from Albania: alternariol, alternariol monomethyl ether, tenuazonic acid, and tentoxin. World Mycotoxin Journal, 12(1), 89–99.

36. Van der Merwe, K. J., Steyn, P. S., Fourie, L., Scott, D. B., and Theron, J. J. (1965). Ochratoxin A, a toxic metabolite produced by Aspergillus ochraceus Wilh. Nature, 205 (976), 1112-1113, doi: 10.1038/2051112a0.

37. Yanfei, T., Shuyu, X., Fanfan, X., Aimei, L., Yanxin, W., Dongmei, Ch., et al., (2018). Ochratoxin A: Toxicity, oxidative stress and metabolism. Food and Chemical Toxicology, 112, 320-331.

38. Zain, M. E. (2011). Impact of mycotoxins on humans and animals. Journal of Saudi Chemical Society, 15/2, 129-144, doi: 10.1016/j.jscs.2010.06.006.

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Published

2025-12-31

How to Cite

TOPI , G., & TOPI , D. (2025). Ochratoxin a in Maize: Origin, Occurrence, and Health Implications, Albania Case. Agricultural and Food Technologies, 3(1), 119-131. https://doi.org/10.65888/icraft.3.1.13